Clinical Research

Ingredient Studies†

Benfotiamine (Vitamin B1)

 Abstract – Comparative bioavailability of various thiamine derivatives after oral administration

 Abstract – Pharmacokinetics of thiamine derivatives especially of benfotiamine

 Full Study – Benfotiamine blocks three major of pathways hyperglycemic damage and prevents experimental diabetic neuropathy

 Abstract – A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy

 Full Study – Benfotiamine in diabetic polyneuropathy (BENDIP): Results of a randomised, double blind, placebo controlled clinical study

 Abstract – Effectiveness of different benfotiamine dosage regimens in the treatment of painful diabetic neuropathy

 Abstract – Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats

Methylcobalamin (Vitamin B12)

Full Study – Effects of methylcobalamin on diabetic neuropathy

 Abstract – Clinical usefulness of intrathecal injection of methylcobalamin in patients
with diabetic neuropathy

 Abstract – Ultra-high dose methylcobalamin promotes nerve regeneration in
experimental acrylamide neuropathy

 Full Study – Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture

 Abstract – Methylcobalamin (methyl-B12) promotes regeneration of motor nerve terminals degenerating in anterior gracile muscle of gracile axonal dystrophy (GAD) mutant mouse

Other Ingredients

 Abstract – The influence of pyridoxine in diabetic peripheral neuropathy (vitamin B6)

 Abstract – Neuroprotective effects of folic acid on experimental diabetic peripheral neuropathy

 Full Study – Dietary reference intakes for thiamin, riboflavin, vitamin B6, folate, vitamin B12, etc.

 Vitamin D (full study) – Vitamin D for the treatment of painful diabetic neuropathy